Proposed Occupational Exposure Limits for Select Ethylene Glycol Ethers Using PBPK Models and Monte Carlo Simulations

Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations.

Methoxyethanol (ethylene glycol monomethyl ether, EGME), ethoxyethanol (ethylene glycol monoethyl ether, EGEE), and ethoxyethyl acetate (ethylene glycol monoethyl ether acetate, EGEEA) are all developmental toxicants in laboratory animals. Due to the imprecise nature of the exposure data in epidemiology studies of these chemicals, we relied on human and animal pharmacokinetic data, as well as a...

Assessing Models using Monte Carlo Simulations

We establish a framework for assessing the validity of a given model using Monte Carlo simulations and inferences based on sampling distributions. Using this framework, we show that geometric brownian motion alone cannot generate a majority of the patterns in the distribution of stock returns and wealth creation. Our paper represents an often overlooked departure from the traditional way of val...

Occupational exposure to glycol ethers and ovarian function.

T he simultaneously hydrophilic and lipophilic properties of glycol ethers account for their use as solvents in a wide range of industrial and domestic products, including paints, varnishes, cleaning agents, and cosmetics. These dozens of compounds are grouped into two main classes: ethylene glycol ethers (EGEs) and propylene glycol ethers (PGEs). Because animal experiments show several EGEs to...

Occupational Exposure Limits for 1,2-dibromoethane (ethylene dibromide)

Analyses of ethylene glycol monoalkyl ethers and their proposed metabolites in blood and urine.

Glycol ethers are known to produce embryotoxic and teratogenic effects in a variety of animal species. In addition, testicular edema and tubular atrophy have been reported. The health effects of this class of compounds are not known in humans, despite the fact that these solvents are widely used in industry. In order to evaluate potential effects in humans, it is first necessary to estimate exp...